Raf is an important signal transduction factor used in the mitogen- activated protein kinase MAPK pathway , undertake upstream Ras signal, transmitted to the downstream MEK / ERK, affecting the growth and differentiation of cells. MAPK pathway is one of the most important signals in the human body , it plays a very important role in the cytoplasmic activity and regulation of gene expression . if overexpression or mutation of subtype BRAF in the MAPK signaling pathway of Raf family , it may induce tumor development and progression. Currently Sorafenib is the most popular drug in Raf inhibitor family, has entered the fast-track passage of drug administration , is the first approved for clinical application of a multi-target targeted therapies in the world . It is used for the treatment of liver cancer cells, kidney cancer cells, locally recurrent or metastatic , progressive differentiated thyroid patients. With the gradual deepening of the study , there will be born a greater variety of more efficacy
Raf Inhibitors Drug.
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