Afatinib Intermediate D 314771-76-1

(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine CAS No. 31 4771-76-1  is offered with high quality and attractive price by our company. It is a white powder also called Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl 314771-76-1 with the molecular formula of C18H16ClFN4O2.Appearance: Beige to yellow power solid,Water content≦1.0%
Melting point:174-180℃,Single impurity ≦0.3%,Chiral impurity ≦0.3%,Purity(by HPLC)≧99.0%. Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl CAS 314771-76-1 is a Pharmaceutical Intermediate ,which is used in the synthesis of Afatinib.It offered with high purity is worth to be chosen.

Thera. Category: Anti-cancer

Cas No.: 314771-76-1

Synonym: (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine;N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine;7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl) aMino-6-aMinoquinazoline;Afatinib IMpurity B;Afatinib intermediate D;N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl];Afatinib INT;4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-amine-7-[[(3S)-tetrahydro-3-furanyl]oxy]-

Molecular Formula: C18H16ClFN4O2

Molecular Weight:  374.7966432 

Assay: ≥99.%

Packing: Export worthy packing

lMaterial Safety Data Sheet: Available on request

Usage: Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl is a reactant in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

Related intermedite:
1) 7-Fluoro-6-nitro-4-hydroxyquinazoline, Afatinib Intermediate, CAS 162012-69-3
2) Afatinib Dimaleate 850140-73-7
3) Afatinib  CAS 439081-18-2 
4) trans-4-Dimethylaminocrotonic acid hydrochloride, CAS Number 848133-35-7
5) N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinamine 314771-88-5
6)  (S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline -4,6-diamine(CAS 314771-76-1)
7) 4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline 162012-67-1
7) (S)-3-Hydroxytetrahydrofuran[86087-23-2] 

Product Categories : Intermediates > Anti-Tumor Intermediates